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ANTHRAX (the Greek for " coal,” or " ...

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Originally appearing in Volume V02, Page 108 of the 1911 Encyclopedia Britannica.
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ANTHRAX (the See also:Greek for " See also:coal,” or " See also:carbuncle," so called by the ancients because they regarded it as burning like coal; cf. the See also:French See also:equivalent charbon; also known as fievre charbonneuse, Milzbrand, splenic See also:fever, and See also:malignant pustule)  , an acute, specific, infectious, virulent disease, caused by the Bacillus anthracis, in animals, chiefly See also:cattle, See also:sheep and horses, and frequently occurring in workers in the See also:wool or See also:hair, as well as in those handling the hides or carcases, of beasts which have been affected . Animals.—As affecting See also:wild as well as domesticated animals and See also:man, See also:anthrax has been widely diffused in one or more of its forms, over the See also:surface of the globe . It at times decimates the See also:reindeer herds in See also:Lapland and the Polar regions, and is only too well known in the tropics and in temperate latitudes . It has been observed and described in See also:Russia, See also:Siberia, Central See also:Asia, See also:China, See also:Cochin-China, See also:Egypt, See also:West Indies, See also:Peru, See also:Paraguay, See also:Brazil, See also:Mexico, and other parts of See also:North and See also:South See also:America, in See also:Australia, and on different parts of the See also:African See also:continent, while for other See also:European countries the writings which have been published with regard to its nature, its See also:peculiar characteristics, and the injury it inflicts are innumerable . Countries in which are extensive marshes, or the subsoil of which is tenacious or impermeable, are usually those most frequently and seriously visited . Thus there have been regions notorious for its prevalence, such as the marshes of See also:Sologne, See also:Dombes and See also:Bresse in See also:France; certain parts of See also:Germany, See also:Hungary and See also:Poland; in See also:Spain the See also:half-submerged valleys and the maritime coasts of See also:Catalonia, as well as the Romagna and other marshy districts of See also:Italy; while it is epizootic, and even panzootic, in the swampy regions of See also:Esthonia, See also:Livonia, See also:Courland, and especially of Siberia, where it is known as the Sibirskaja jaswa (Siberian See also:boil-See also:plague) . The records of anthrax,g o back to a very See also:ancient date . It is supposed to be the See also:murrain of See also:Exodus . Classical writers allude to anthrax as if it were the only cattle disease worthy cf mention (see See also:Virgil, Georg. iii.) . It figures largely in the See also:history of the See also:early and See also:middle ages as a devastating pestilence attacking animals, and through them mankind; the See also:oldest See also:Angle) . Saxon See also:manuscripts contain many fantastic recipes, lcechdoms . See also:Pea „ ' H See also:Buckwheat See also:Rice See also:Barley „ ,•',; „ charms and incantations for the prevention or cure of the blacan blezene " (See also:black Blain) and the See also:relief of the " elfshot creatures .

In the 18th and 19th centuries it sometimes spread like an epizootic over the whole of See also:

Europe, from Siberia to France . It was in this malady that disease-producing germs (bacteria) were first discovered, in 1849, by Pollender of Wipperfiirth, and, independently, by veterinary surgeon Brauell of Dorpat, and their real See also:character afterwards verified by C . J . Davaine (1812-1882) of Alfort in 1863; and it was in their experiments with this disease that See also:Toussaint, See also:Pasteur and J . B . Chauveau first showed how to make the morbific See also:poison its own antidote . (See See also:VIVISECTION.) The symptoms vary with the See also:species of See also:animal, the mode of infection, and the seat of the See also:primary See also:lesion, See also:internal or See also:external . In all its forms anthrax is an inoculable disease, transmission being surely and promptly effected by this means, and it may be conveyed to nearly all animals by inoculation of a See also:wound of the skin or through the See also:digestive See also:organs . Cattle, sheep and horses nearly always owe their infection to spores or bacilli ingested with their See also:food or See also:water, and pigs usually See also:contract the disease by eating the flesh of animals dead of anthrax . Internal anthrax, of cattle and sheep, exhibits no premonitory symptoms that can be relied on . Generally the first indication of an outbreak is the sudden See also:death of one or more of the See also:herd or See also:flock . Animals which do not See also:die at once may be noticed to stagger and tremble; the breathing becomes hurried and the See also:pulse very rapid, while the See also:heart beats violently; the internal temperature of the See also:body is high, 104° to 1o6° F.; See also:blood oozes from the See also:nose, mouth and anus, the visible mucous membranes are dusky or almost black .

The animal becomes weak and See also:

list-less, the temperature falls and death supervenes in a few See also:hours, being immediately preceded by See also:delirium, See also:convulsions or See also:coma . While death is usually rapid or sudden when the malady is See also:general, constituting what is designated splenic See also:apoplexy, internal anthrax in cattle is not invariably fatal . In some cases the animal rallies from a first attack and gradually recovers . In the external or localized See also:form, marked by the formation of carbuncles before general infection takes See also:place, death may not occur for several days . The carbuncles may appear in any See also:part of the body, being preceded or accompanied by See also:fever . They are See also:developed in the subcutaneous connective See also:tissue where this is loose and plentiful, in the interstices of the muscles, lymphatic glands, in the mucous membranes of the mouth and See also:tongue (glossanthrax of cattle), pharynx and larynx (anthrax angina of horses and pigs), and the rectum . They begin as small circumscribed swellings which are warm, slightly painful and oedematous . In from two to eight hours they attain a considerable See also:size, are See also:cold, painless and gangrenous, and when they are incised a quantity of a blood-stained gelatinous exudate escapes . When the swellings have attained certain proportions symptoms of general infection appear, and, See also:running their course with See also:great rapidity, cause death in a few hours . Anthrax of the See also:horse usually begins as an See also:affection of the See also:throat or bowel . In the former there is rapid obstructive oedema of the mucous membrane of the pharynx and larynx with swelling of the throat and See also:neck, fever, salivation, difficulty in swallowing, noisy breathing, frothy See also:discharge from the nose and threatening suffocation . General invasion soon ensues, and the horse may die in from four to sixteen hours .

Phoenix-squares

The intestinal form is marked by high temperature, great prostration, small thready pulse, tumultuous See also:

action of the heart, laboured breathing and symptoms of abdominal See also:pain with straining and See also:diarrhoea: When moved the horse staggers and trembles . Profuse sweating, a falling temperature and cyanotic mucous membranes indicate the approach of a fatal termination . In splenic fever or splenic apoplexy, the most marked alterations observed after death are—the effects of rapid decomposition, evidenced by the foul odour, disengagement of See also:gas beneath the skin and in the tissues and cavities of the body, yellow or yellowish-red gelatinous exudation into and between the muscles, effusion of citron or See also:rust-coloured fluid in various cavities, extravasations of blood and See also:local congestions throughout the107 body, the blood in the vessels generally being very dark and See also:tar-like . The most notable feature, however, in the See also:majority of cases is the enormous enlargement of the See also:spleen, which is en-gorged with blood to such an extent that it often ruptures, while its tissue is changed into a See also:violet or black fluid See also:mass . The bacillus of anthrax, under certain conditions, retains its vitality for a See also:long See also:time, and rapidly grows when it finds a suitable See also:field in which to develop, its mode of multiplication being by scission and the formation of spores, and depending, to a great extent at least, on the presence of See also:oxygen . The morbid action of the bacillus is indeed said to be due to its See also:affinity for oxygen; by depriving the red corpuscles of the blood of that most essential gas, it renders the vital fluid unfit to sustain See also:life . See also:Albert Hoffa and others• assert that the fatal lesigns are produced by the poisonous action of the toxins formed by the bacilli and not by the blocking up of the See also:minute blood-vessels, or the See also:abstraction of oxygen from the blood by the bacilli . It was by the cultivation of this micro-organism, or attenuation of the See also:virus, that Pasteur was enabled to produce a prophylactic remedy for anthrax . His See also:discovery was first made with regard to the See also:cholera of fowls, a most destructive disorder which annually carries off great See also:numbers of poultry . Pasteur produced his inoculation material by the cultivation of the bacilli at a temperature of 42° C. in oxygen . Two vaccines are required . The first or weak vaccine is obtained by incubating a See also:bouillon culture for twenty-four days at 42° C., and the second or less attenuated vaccine by incubating a bouillon culture, at the same temperature, for twelve days .

Pasteur's method of protective inoculation comprises two inoculations with an See also:

interval of twelve days between them . See also:Immunity, established in about fifteen days after the injection of the second vaccine, lasts from nine months to a See also:year . Toussaint had, previous to Pasteur, attenuated the virus of anthrax by the action of See also:heat; and Chauveau subsequently corroborated by numerous experiments the value of Toussaint's method, demonstrating that, according to the degree of heat to which the virus is subjected, so is its inocuousness when transferred to a healthy creature . In outbreaks of anthrax on farms where many animals are exposed to infection immediate temporary See also:protection can be conferred by the injection of anthrax serum . Human Beings.—For many years cases of sudden death had been observed to occur from time to time among healthy men engaged in woollen manufactories, particularly in the See also:work of sorting or combing wool . In some instances death appeared to be due to the See also:direct inoculation of some poisonous material into the body, for a form of See also:malignant pustule was observed upon the skin; but, on the other See also:hand, in not a few cases without any external manifestation, symptoms of blood-poisoning, often proving rapidly fatal, suggested the See also:probability of other channels for the introduction of the disease . In 188o the occurrence of several such cases among woolsorters at See also:Bradford, reported by Dr J . H . See also:Bell of that See also:town, led to an See also:official inquiry in See also:England by the Local See also:Government See also:Board, and an elaborate investigation into the See also:pathology of what was then called " woolsorters' disease " was at the same time conducted at the See also:Brown Institution, See also:London, by See also:Professor W . S . See also:Greenfield . Among the results of this inquiry it was ascertained: (1) that the disease appeared to be identical with that occurring among sheep and cattle; (2) that in the blood and tissues of the body was found in abundance, as in the disease in animals, the Bacillus anthracis, and (3) that the skins, hair, wool, &c., of animals dying of anthrax retain this infecting organism, which, under certain conditions, finds ready See also:access to the bodies of the workers .

Two well-marked forms of this disease in man are recognized, " external anthrax " and " internal anthrax." In external anthrax the infecting See also:

agent is accidentally inoculated into some portion of skin, the seat of a slight See also:abrasion, often the hand, See also:arm or See also:face . A minute swelling ,soon appears at the part, and develops into a vesicle containing serum or bloody See also:matter, and varying in size, but seldom larger than a See also:shilling . This vesicle speedily bursts and leaves an ulcerated or sloughing surface, See also:round about which are numerous smaller vesicles which undergo similar changes, and the whole affected part becomes hard and See also:tender, while the surrounding surface participates in the inflammatory action, and the neighbouring lymphatic glands are also inflamed . This See also:condition, termed " malignant pustule," is frequently accompanied with severe constitutional disturbance, in the form of fever, delirium, perspirations, together with great prostration and a tendency to death from septicaemia, although on the other hand recovery is not uncommon . It was repeatedly found that the matter taken from the vesicle during the progress of the disease, as well as the blood in the body after death, contained the Bacillus anthracis, and when inoculated into small animals produced rapid death, with all the symptoms and See also:post-mortem appearances characteristic of the disease as known to affect them . In internal anthrax there is no visible local manifestation of the disease, and the spores or bacilli appear to gain access to the See also:system from the See also:air charged with them, as in rooms where the contaminated wool or hair is unpacked, or again during the See also:process of sorting . The symptoms usually observed are those of rapid See also:physical prostration, with a small pulse, somewhat lowered temperature (rarely fever), and quickened breathing . Examination of the See also:chest reveals inflammation .of the lungs' and pleura . In some cases death takes place by collapse in less than one See also:day, while in others the fatal issue is postponed for three or four days, and is preceded by symptoms of blood-poisoning, including rigors, perspirations, extreme exhaustion, &c . In some cases of internal anthrax the symptoms are more intestinal than pulmonary, and consist in severe exhausting diarrhoea, with vomiting and rapid sinking . Recovery from the internal variety, although not unknown, is more rare than from the external, and its most striking phenomena are its sudden onset in the midst of apparent See also:health, the rapid development of physical prostration, and its tendency to a fatal termination despite treatment . The post-mortem appearances in internal anthrax are such as are usually observed in septicaemia, but in addition See also:evidence of extensive inflammation of the lungs, pleura and bronchial glands has in most cases been met with .

The blood and other fluids and the diseased tissues are found loaded with the Bacillus anthracis . Treatment in this disease appears to be of but little avail, except as regards the external form, where the malignant pustule may be excised or dealt with early by strong caustics to destroy the affected textures . For the relief of the general constitutional symptoms, See also:

quinine, stimulants and strong nourishment appear to be the only available means . An See also:anti-anthrax serum has also been tried . As preventive See also:measures in woollen manufactories, the disinfection of suspicious material, or the wetting of it before handling, is recommended as lessening the See also:risk to the workers . (J .

End of Article: ANTHRAX (the Greek for " coal,” or " carbuncle," so called by the ancients because they regarded it as burning like coal; cf. the French equivalent charbon; also known as fievre charbonneuse, Milzbrand, splenic fever, and malignant pustule)
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