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See also:ATROPHY (Gr. It- priv., rpo4, nourishment) , a See also:term in See also:medicine used to describe a See also:state of wasting due to some interference with the See also:function of healthy See also:nutrition (see See also:PATHOLOGY) . In the living organism there are always at See also:work changes involving the See also:waste of its component tissues, which render necessary, in See also:order to maintain and preserve See also:life, the See also:supply and proper assimilation of nutritive material . It is also essential for the See also:maintenance of See also:health that a due relation exist between these processes of waste and repair, so that the one may not be in excess of the other . When the See also:appropriation of nutriment exceeds the waste, See also:hypertrophy (q.v.) or increase in bulk of the tissues takes See also:place . When, on the other See also:hand, the supply of nutritive See also:matter is suspended or diminished, or when the See also:power of assimilation is impaired, See also:atrophy or wasting is the result . Thus the whole See also:body becomes atrophied in many diseases; and in old See also:age every See also:ATTA 877 See also:part of the See also:frame, with the single exception of the See also:heart, under-goes atrophic See also:change . Atrophy may, however, affect single See also:organs or parts of the body, irrespective of the See also:general state of nutrition, and this may be brought about in a variety of ways . One of the most frequently observed of such instances is atrophy from disuse, or cessation of function . Thus, when a See also:limb is deprived of the natural power of See also:motion, either by See also:paralysis or by painful See also:joint disease, the See also:condition of exercise essential to its nutrition being no longer fulfilled, atrophy of all its textures sooner or later takes place . The See also:brain in imbeciles is frequently observed to be shrivelled, and in many cases of See also:blindness there is atrophy of the optic See also:nerve and optic See also:tract . This See also:form of atrophy is likewise well exemplified in the See also:case of those organs and structures of the body 'which subserve important ends during foetal life, but which, ceasing to be necessary after See also:birth, undergo a sort of natural atrophy, such as the thymus gland, and certain vessels specially concerned in the foetal circulation . The uterus after parturition undergoes a certain amount of atrophy, and the ovaries, after the See also:child-bearing See also:period, become shrunken . Atrophy of a part may also be caused by interruption to its normal See also:blood-supply, as in the case of the ligature or obstruction of an artery . Again, See also:long-See also:standing disease, by affecting the nutrition of an See also:organ and by inducing the See also:deposit of morbid products, may result in atrophy, as frequently happens in affections of the See also:liver and kidneys . Parts that are subjected to continuous pressure are liable to become atrophied, as is sometimes seen in See also:internal organs which have been pressed upon by tumours or other morbid growths, and is well illustrated in the See also:Chinese practice of See also:foot-binding . Atrophy may See also:manifest itself simply by loss of substance; but, on the other hand, it is often found to co-exist with degenerative changes in the textures affected and the formation of See also:adventitious growth, so that the part may not be reduced in bulk although atrophied as regards its proper structure . Thus, in the case of the heart, when affected with fatty degeneration, there is atrophy of the proper See also:muscular texture, but as this is largely replaced by fatty matter, the organ may undergo no diminution in See also:volume, but may, on the contrary, be increased in See also:size . Atrophy is usually a See also:gradual and slow See also:process, but sometimes it proceeds rapidly . In the disease known by the name of acute yellow atrophy of the liver, that organ undergoes such rapidly destructive change as results in its shrinking to See also:half, or one-third, of its normal size in the course of a few days . The term progressive muscular atrophy (synonyms, wasting or creeping palsy) is applied to an See also:affection of the muscular See also:system, which is characterized by the atrophy and subsequent paralysis of certain muscles, or See also:groups of muscles, and is associated with morbid changes in the anterior roots of the nerves of the See also:spinal See also:cord . This disease begins insidiously, and is often first observed to affect the muscles of one hand, generally the right . The See also:attention of the sufferer is first attracted by the power of the hand becoming weakened, and then there is found to be a wasting of certain of its muscles, particularly those of the See also:ball of the thumb . Gradually other muscles in the arms and legs become affected in a similar manner, their atrophy being attended with a corresponding diminution in power . Although sometimes arrested, this disease tends to progress, until in course of See also:time the greater part of the muscular system is implicated and a fatal result ensues .
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