Online Encyclopedia

CBH17NO4 BERBERINE

Online Encyclopedia
Originally appearing in Volume V03, Page 764 of the 1911 Encyclopedia Britannica.
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CBH17NO4 BERBERINE, an alkaloid occurring together with the alkaloids oxyacanthine C16H19NO3, berbamine C13H19NO3, hydrastine C21H21N06, and canadine C20H21NO4, in Berberis vulgaris; it also occurs in other plants, Berberis aristata, B. aquifolium, Hydrastis canadensis, &c. It is a yellow, crystalline solid, insoluble in ether and chloroform, soluble in 41 parts of water at 2 1°, and moderately soluble in alcohol. It is a monacid base; the hydrochloride, C2BH17NO4•HCI, is insoluble in cold alcohol, ether and chloroform, and soluble in 500 parts of water; the acid sulphate, C20H17N04•112SO4, dissolves in about loo parts of water. Canadine is a tetrahydroberberine. Its constitution was worked out by W. H. Perkin (J.C.S., 1889, 55, p. 63; 189o, 57, p. 991). This followed from a study of the decomposition products, there being obtained hemipinic acid (CH3O)2C6H2(000H)2, and a substance which proved to be to- amino -ethyl- piperonyl carboxylic acid, CH2O2:C6H2•COOH•CH2•CH2NH2. His formula was modified by Gadamer (Abs. J.C.S., 1902, I, p. 555), who made the free base an aldehyde, but the salts of an iso-quinolinium type. This formula, which necessitates the presence of two asymmetric carbon atoms in an alkyl tetrahydroberberine, has been accepted by M. Freund and F. Mayer (Abs. J.C.S., 1907, I, p. 632), who showed that two racemic propyl tetrahydroberberines are produced when propyl dihydroberberine is reduced.
End of Article: CBH17NO4 BERBERINE
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