BIBIRINE, or BEBEEZZINE, C19H21NO3  , an alkaloid obtained from the bark and fruit of the greenheart (q.v.) tree, Nectandra rodiaei, called bibiru or sipiri in Guiana, where the tree grows . The substance was discovered about the year 1835 by Hugh Rodie, a surgeon in Demerara, who used it as a febrifuge in substitution for quinine .