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See also:CAFFEINE, or THEINE (1.3.7 trimethyl 2 . 6 dioxypurin) , C$ His N4 02 . H ? O, a substance found in the leaves and beans of the See also:coffee See also:tree, in See also:tea, in See also:Paraguay tea, and in small quantities in See also:cocoa and in the See also:kola See also:nut . It may be extracted from tea or coffee by boiling with See also:water, the dissolved See also:tannin precipitated by basic See also:lead acetate, the See also:solution filtered, excess of lead precipitated by sulphuretted See also:hydrogen and the filtered liquid then evaporated to See also:crystallization; or, tea is boiled with water, and the whole then evaporated to a See also:syrup, which is mixed with slaked See also:lime, evaporated to dryness on the water-See also:bath and extracted with See also:chloroform (P . Cazeneuve, See also:Bull. de la See also:soc. chim. de See also:Paris, 1876-1877, 27, p . 199) . Synthetically it may be prepared by the methylation of See also:silver theobromine and silver theophyllin or by boiling heteroxanthine with methyl iodide and potash . E . See also:Fischer and L . Ach (Berichte, 1895, 28, p . 3135) have synthesized it from dimethyl alloxan, whilst W . Traube (Berichte, 1900, 33, p . 3435) has obtained it from 1 . 3 diamethyl 4 . 5 diamino 2.6 dioxypyrimidine . On the constitution of See also:caffeine see BURIN and also E . Fischer (Annalen, 1882, 215, p . 253) . Caffeine crystallizes in See also:long silky needles, which are slightly soluble in See also:cold water . It becomes anhydrous at ro0° C. and melts at 234° to 23 5° C . It has a faint See also:bitter See also:taste and gives salts with See also:mineral acids . On oxidation with nitric See also:acid caffeine gives cholesterophane (dimethyl parabanic acid), but if See also:chlorine water be used as the oxidant, then it yields monomethyl See also:urea and dimethyl alloxan (E . Fischer) . |
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