Online Encyclopedia

CRH6N2 CINNOLIN

Online Encyclopedia
Originally appearing in Volume V06, Page 377 of the 1911 Encyclopedia Britannica.
Spread the word: del.icio.us del.icio.us it!
CRH6N2 CINNOLIN, a compound isomeric with phthalazine, prepared by boiling dihydrocinnolin dissolved in benzene with freshly precipitated mercuric oxide. The solution is filtered and the hydrochloride of the base precipitated by alcoholic hydrochloric acid; the free base is obtained as an oil by adding caustic soda. It may be obtained in white silky needles, melting at 24-25° C. and containing a molecule of ether of crystallization by cooling the oil dissolved in ether. The free base melts at 39° C. It is a strong base, forming stable salts with mineral acids, and is easily soluble in water and in the ordinary organic solvents. It has a taste resembling that of chloral hydrate, and leaves a sharp irritation for some time on the tongue; it is also very poisonous (M. Busch and A. Rast, Berichte, 1897, 30, p. 521). Cinnolin derivatives are obtained from oxycinnolin carboxylic acid, which is formed by digesting orthophenyl propiolic acid diazo chloride with water. Oxycinnolin carboxylic acid on heating gives oxycinnolin, melting at 2250, which with phosphorus pentachloride gives chlorcinnolin. This substance is reduced by iron filings and sulphuric acid to dihydrocinnolin. The relations of these compounds are here shown: cans C-OH /CH ' /NsNa f~ N N C.COOH O-phenyl propiolic Oxycinnolin Oxycinnolin amain acid diazo hydroxide carboxylic acid
End of Article: CRH6N2 CINNOLIN
[back]
JOHN CINNAMUS [KINNAMOS]
[next]
CINO DA PISTOIA (127o-1836)

Additional information and Comments

There are no comments yet for this article.
» Add information or comments to this article.
Please link directly to this article:
Highlight the code below, right click and select "copy." Paste it into a website, email, or other HTML document.