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See also:COPAIBA, or COPAIVA (from Brazilian cupauba) , an oleo-See also:resin —sometimes termed a See also:balsam—obtained from the See also:trunk of the Copaifera Lansdorfii (natural See also:order See also:Leguminosae) and from other See also:species of Copaifera found in the See also:West Indies and in the valley of the See also:Amazon . It is a somewhat viscous transparent liquid, occasionally fluorescent and of a See also:light yellow to See also:pale See also:golden See also:colour . The odour is aromatic and very characteristic, the See also:taste acrid and See also:bitter . It is insoluble in See also:water, but soluble in See also:absolute See also:alcohol, See also:ether and the fixed and volatile See also:oils . Its approximate See also:composition is more than 50% of a volatile oil and less than 50% of a resin . The pharmacopoeias contain the oleo-resin itself, which is given in doses of from a See also:half to one drachm, and the oleum copaibae, which is given in doses of from five to twenty minims, but which is inferior, as a medicinal See also:agent, to the oleo-resin . See also:Copaiba shares the pharmacological characters of volatile oils generally . Its distinctive features are its disagree-able taste and the unpleasant eructations to which it may give rise, its irritant See also:action on the See also:intestine in any but small doses, its irritant action on the skin, often giving rise to an erythematous eruption which may be mistaken for that of See also:scarlet See also:fever, and its exceptionally marked stimulant action on the kidneys . In large doses this last action may See also:lead to renal inflammation . The resin is excreted in the urine and is continually mistaken for See also:albumin since it is precipitated by nitric See also:acid, but the precipitate is re-dissolved, unlike albumin, on See also:heating . Its nasty taste, its irritant action on the bowel, and its characteristic odour in the breath, prohibit its use—despite its other advantages—in all diseases but gonorrhoea . For this disease it is a valuable remedy, but it must not be administered until the acute symptoms have subsided, else it will often increase them . It is best given in cachets or in three times its own bulk of See also:mucilage of See also:acacia . Various devices are adopted to disguise its odour in the breath . The clinical See also:evidence clearly shows that none of the numerous See also:vegetable rivals to copaiba is equal to it in therapeutic value . |
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