35º58N 83º55W, pop (2000e) 173 900. City port in Knox Co, E Tennessee, USA; on the Tennessee R, 160 km/100 mi NE of Chattanooga; located in a broad valley between the Cumberland Mts to the NW and the Great Smoky Mts to the SE; founded, 1768; birthplace of James Agee and Quentin Tarantino; university (1794); railway; major trade and shipping centre; livestock and tobacco market; marble, plastics, textiles, chemicals, aluminium.