41°30N 81°42W, pop (2000e) 478 400. Seat of Cuyahoga Co, NE Ohio, USA; port on L Erie at the mouth of the Cuyahoga R; developed with the opening of the Ohio and Erie Canal, 1827; city status, 1836; largest city in Ohio; airfield; railway; three universities (1826, 1886, 1923); machinery, metals and metal products, electronics, transportation equipment; medical research centre; professional teams, Indians (baseball), Cavaliers (basketball), Browns (football); Cleveland Symphony Orchestra; Play House, Holden Arboretum, Museum of Art.