Online Encyclopedia


Online Encyclopedia
Originally appearing in Volume V08, Page 870 of the 1911 Encyclopedia Britannica.
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ECGONINE, in chemistry, C9H15NO3, a cycloheptane derivative with a nitrogen bridge. It is obtained by hydrolysing cocaine with acids or alkalis, and crystallizes with one molecule of water, the crystals melting at 1980 to 199° C. It is laevo-rotatory, and on warming with alkalis gives iso-ecgonine, which is dextro-rotatory. It is a tertiary base, .and has also the properties of an acid and an alcohol. When boiled with caustic baryta it gives methyl-amine. It is the carboxylic acid corresponding to tropine, for it yields the same products on oxidation, and by treatment with phosphorus pentachloride 'is converted into anhydroecgonine, C9H13NO2, which, when heated to 28o° C. with hydrochloric acid, splits out carbon dioxide and yields tropidine, C8H13N. Anhydroecgonine melts at 235° C., and has an acid and a basic character. It is an unsaturated compound, and on oxidation with potassium permanganate gives succinic acid. It is apparently a tropidine monocarboxylic acid, for on exhaustive methylation it yields cycloheptatriene-1.3.5-carboxylic acid-7. Sodium in amyl alcohol solution reduces it to hydroecgonidine C9H15NO2, while moderate oxidation by potassium permanganate converts it into norecgonine. The presence of the heptamethylene ring in these compounds is shown by the production of suberone by the exhaustive methylation, &c., of hydroecgonidine ethyl ester (see POLYMETHYLENES and TROPINE). The above compounds may be represented as: CH;.—CH—CI H COON CH2—CH—CH'COOH CH2—CH—C H'COOH N'CH3 CH'OH NCH3 (H NCH3 CI H2 CH2—CH—c1I2 CH2—CH---CH CH2—CH—CH2 Ecgonine Anhydroecgonine Hydroecgonidine
End of Article: ECGONINE
ECGFRITH (d. 685)

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