Online Encyclopedia

GROUP XIX

Online Encyclopedia
Originally appearing in Volume V21, Page 352 of the 1911 Encyclopedia Britannica.
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GROUP XIX. Alkaloids.—This embraces a very large number of important pharmacological substances, which differ a good deal in the details of their action, but they all act upon muscle and nerve tissue. Some of them affect only certain portions of the nervous system, others have a much wider range of action; they may act in either case as stimulants or as depressants, and hence the symptoms produced by them vary very greatly. 1. Morphine and the other opium alkaloids (codeine, narcotine, laudanine, &c.) have two prominent actions–a narcotic followed by a tetanic action. In morphine, on the higher animals at least, the narcotic action is very marked, the tetanizing action slightly so; while in thebaine there is little narcotic effect, but a tetanizing action like that of strychnine. Morphine exercises its effects chiefly upon the cerebrum and the medulla oblongata in man. It has in addition a markedly depressing action upon the respiratory centre, it lessens all the secretions except the sweat, and diminishes bowel peristalsis and the size of the pupil. Men are much more affected by it than birds, rabbits, dogs and most other animals. Cats, however, show marked symptoms of cerebral excitement and increase of the reflexes. Compared with morphine, codeine and the other alkaloids are only slightly narcotizing. 2. Strychnine and brucine very closely resemble each other in action, and under this heading curarine may also be included. These bodies stimulate the grey matter in the spinal cord and cause tetanic convulsions. In the case of curare these are masked almost at once by paralysis of the terminations of the motor nerves. 3. Caffeine is the active principle in tea, coffee, kola, mate and guarana; while thcobromine, a body closely allied to it, is found in cocoa and chocolate. They both stimulate the grey nerve-cells in the brain and cord, this being the foundation of their dietetic value and their use as nervine stimulants. They also markedly increase the secretion of urine by stimulating the secreting cells of the kidneys. 4. Cocaine is the active principle of the coca leaf, which is chewed as a stimulant-narcotic in Peru and Bolivia. Small doses excite the nervous system, while larger doses are depressing. The chief action of cocaine from a practical point of view is its power of paralysing the terminations of sensory nerves. 5. Atropine, hyoscyamine, homatropine, duboisine, daturine and some other bodies have a paralysing action upon the ends of the motor and secretory nerves. They therefore lessen all the secretions, and among other actions dilate the pupil and increase the rapidity of the heart by paralysing the vagus. In addition they have a stimulating action on the central nervous system. 6. Nicotine, piturine and loheline are the active principles of tobacco and other substances which are smoked as stimulant narcotics. In large doses they are powerful nerve poisons, but as usually taken they exercise a gently stimulant effect upon the nervous system. Pilocarpine has an action closely allied to that of nicotine, but as it is much less poisonous (the effects produced by small doses being chiefly excessive sweating and salivation), it is capable of being utilized in medicine. Muscarine has a very close resemblance in action to pilocarpine. 7. Physostigmine, the active principle of the Calabar bean, acts chiefly as a stimulant to voluntary and involuntary muscles, and at the same time exercises a depressing effect upon the spinal cord. It contracts the pupil. 8. Conine, gelseminine and sparteine all exert a paralysing effect on the terminations of the motor nerves, to the implication of which the weakened gait and other symptoms are due. 9. Aconitine, delphinine and many of their derivatives have a very widespread depressing action on muscle and nerve. 10. Apomorphine is essentially a muscle poison, but owing to the fact that minute doses stimulate the vomiting centre and cause emesis before any other symptoms are observable, its emetic action is the most prominent effect in man. ft. Emetine acts as a gradual depressant to the nervous system in animals. In man its chief effect is its emetic action, which seems to be due entirely to local irritation of the stomach. 12. Quinine. Several of the other alkaloids found in cinchona bet-lc act very much like quinine. They all depress the conducting pcwer and the grey matter of the spinal cord, and to a much less extent that of the brain. They lessen the general metabolism and lower febrile temperature. The cinchona alkaloids have a specific-ally poisonous effect on the parasites of malaria when present in human blood, and are poisonous to all low organisms. 13. Phenacetin, acetanilide, phenazone and many similar bodies act as antipyretics in virtue of an action on the heat-regulating centres in the cerebrum.
End of Article: GROUP XIX
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