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HYPERTROPHY (Gr. inrEp, over, and rpo...

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Originally appearing in Volume V14, Page 201 of the 1911 Encyclopedia Britannica.
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HYPERTROPHY (Gr. inrEp, over, and rpo(A, nourishment)  , a See also:term in See also:medicine employed to designate an abnormal increase in bulk of one or more of the See also:organs or component tissues of the See also:body (see See also:PATHOLOGY) . In its strict sense this term can only be applied where the increase affects the natural textures of a See also:part, and is not applicable where the enlargement is due to the presence of some extraneous morbid formation . See also:Hypertrophy of a part may See also:manifest itself either by simply an increase in the See also:size of its constituents, or by this combined with an increase in their number (hyperplasia) . In many instances both are associated . The conditions giving rise to hypertrophy are the See also:reverse Other symptoms are very varied and differ widely in different of those described as producing See also:ATROPHY (q.v.) . They are concisely stated by See also:Sir See also:James See also:Paget as being chiefly or only three, namely: (1) the increased exercise of a part in its healthy functions; (2) an increased See also:accumulation in the See also:blood of the particular materials which a part appropriates to its See also:nutrition or in secretion; and (3) an increased afflux of healthy blood . Illustrations are furnished of the first of these conditions by the high development of See also:muscular See also:tissue under habitual active exercise; of the second in the See also:case of obesity, which is an hyper-See also:trophy of the fatty tissues, the elements of which are furnished by the blood; and of the third in the occasional overgrowth of See also:hair in the neighbourhood of parts which are the seat of inflammation . Obviously therefore, in many instances, hypertrophy cannot be regarded as a deviation from See also:health, but rather on the contrary as indicative of a high degree of nutrition and See also:physical See also:power . Even in those cases where it is found associated with disease, it is often produced as a salutary effort of nature to compensate for obstructions or other difficulties which have arisen in the See also:system, and thus to See also:ward off evil consequences . No better example of this can be seen than in the case of certain forms of See also:heart disease, where from defect at some of the natural orifices of that See also:organ the onward flow of the blood is interfered with, and would soon give rise to serious embarrassment to the circulation, were it not that behind the seat of obstruction the heart gradually becomes hypertrophied, and thus acquires greater propelling power to overcome the resistance in front . Again, it has been noticed, in the case of certain See also:double organs such as the kidneys, that when one has been destroyed by disease the other has become hypertrophied to such a degree as enables it to See also:discharge the functions of both . Hypertrophy may, however, in certain circumstances constitute a disease, as in See also:goitre and See also:elephantiasis (q.v.), and also in the case of certain tumours and growths (such as cutaneous excrescences, fatty tumours, mucous polypi, &c.), which are simply enlargements of normal textures .

Hypertrophy does not in all cases involve an increase in bulk; for, just as in atrophy there may be no diminution in the size of the affected organ, so in hypertrophy there may be no increase . This is See also:

apt to be the case where certain only of the elements of an organ undergo increase, while the others remain unaffected or are actually atrophied by the pressure of the hypertrophied tissue, as is seen in the disease known as cirrhosis of the See also:liver . A See also:spurious hypertrophy is observed in the rare disease to which G . B . See also:Duchenne applied the name of pseudo-hypertrophic See also:paralysis . This ailment, which appears to be confined to See also:children, consists essentially of a progressive loss of power accompanied with a remarkable enlargement of certain muscles or See also:groups of muscles, more rarely of the whole muscular system . This increase of bulk is, however, not a true hypertrophy, but rather an excessive development of connective tissue in the substance of the muscles, the proper texture of which tends in consequence to undergo atrophy or degeneration . The See also:appearance presented by a See also:child suffering from this disease is striking . The attitude and gait are remarkably altered, the child See also:standing with shoulders thrown back, small of the back deeply curved inwards, and legs wide apart, while walking is accompanied with a See also:peculiar swinging or racking See also:movement . The calves of the legs, the buttocks, the muscles of the back, and occasionally other muscles, are seen to be unduly enlarged, and contrast strangely with the See also:general feebleness . The progress of the disease is marked by increasing failure of locomotory power, and ultimately by See also:complete paralysis of the limbs . The malady is little amenable to treatment, and, although often prolonged for years, generally proves fatal before the See also:period of maturity .

End of Article: HYPERTROPHY (Gr. inrEp, over, and rpo(A, nourishment)
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