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See also:MONSTER (See also:Lat. monstrum, from See also:root of monere, to warn; i.e. something terrible or portentous) . In See also:zoology, monsters or monstrous births are the subject of See also:Animal Teratology, a See also:department of morphological See also:science treating of deviations from the normal development of the embryo . The See also:term " embryo " is conventionally limited, in human See also:anatomy, to the ovum in the first three months of its See also:intra-uterine existence, while it is still developing or acquiring the rudiments of its See also:form, the term " foetus " being applied to it in the subsequent months during which the organism grows on the lines of development already laid down . It is mostly in the first or embryonic See also:period that those deviations from the normal occur which See also:present themselves as monstrosities at the See also:time of See also:birth; these See also:early traces of deviation within the embryo may be slight, but they " grow with its growth and strengthen with its strength," until they amount to irreparable defects or accretions, often incompatible with extra-uterine See also:life . The name of " teratology," introduced by See also:Etienne See also:Geoffroy St Hilaire (1822), is derived from rEpas, the See also:equivalent of monstrum; teratology is a term new enough to have none but scientific associations, while the Latin word has a See also:long See also:record of superstitions identified with it . The myths of See also:siren, satyr, See also:Janus, cyclops and the like, with the corresponding figures in See also:Northern See also:mythology, find a remote anatomical basis in monstrosities which have, for the most See also:part, no life except in the foetal See also:state . The mythology of giants and dwarfs is, of course; better founded . The term See also:monster was originally used in the same sense as portent . See also:Luther 1 speaks of the birth of a monstrous See also:calf, evidently the subject of contemporary talk, as pointing to some See also:great impending See also:change, and he expresses the See also:hope that the See also:catastrophe might be the Last See also:Day itself . The rise of more scientific views will be sketched in the course of the See also:article . Although monstrosities, both in the human See also:species and in other animals, tend to repeat certain definite types of erroneous development, they do not fall readily into classes . The most usual grouping (originally suggested by G . L . L . See also:Buffon, 1800) is into monstra per excessum, monstra per defectum, and monstra per fabricam alienam . It seems useful, however, to See also:place the more See also:simple cases of excess and of defect See also:side by side; and it is necessary, above all, to See also:separate the See also:double monsters from the single, the theory of the former being a distinct See also:chapter in teratology . 1 . Monstrosities in a Single See also:Body.—The abnormality may extend to the body throughout, as in well-proportioned giants and dwarfs; or it may affect a certain region or member, as—to take the simplest See also:case—when there is a See also:finger or toe too many or too few . It is very See also:common for one malformation to be correlated with several others, as in the extreme case of acardiac monsters, in which the non-development of the See also:heart is associated with the non-development of the See also:head, and with other See also:radical defects . Giants are conventionally limited to persons over 7 ft. in height . The normal proportions of the See also:frame are adhered to more or less closely, except in the See also:skull, which is relatively small; but. accurate measurements, even in the best-proportioned cases, prove, when reduced to a See also:scale, that other parts besides the skull—notably the thigh-See also:bone and the See also:foot—may be undersized though overgrown . In persons who are merely very tall the great stature depends often on the inordinate length of the See also:lower limbs; but in persons over q ft. the lower limbs are not markedly disproportionate . In many cases the muscles and viscera are not sufficient for the overgrown frame, and the individuals are usually, but not always, of feeble intelligence and languid disposition, and See also:short-lived . The See also:brain-case especially is undersized—the Irish See also:giant in the museum of Trinity See also:College, See also:Dublin, is the single exception to this See also:rule—but the bones of the See also:face, and especially the lower See also:jaw, are on a large scale . Giants are never See also:born of gigantic parents; in fact, sterility usually goes with this monstrosity . Their See also:size is some-times excessive at birth, but more often the indications of great stature do not appear till later, it may be as See also:late as the ninth See also:year; they attain their full height before the twenty-first year . They have been more frequently male than See also:female . 1 In a passage quoted by T . L . W . Bischoff from the 19th See also:volume of Luther's See also:works, See also:Halle ed., p . 2416 . Dwarfs are conventionally limited to persons under 4 ft . They are more likely than giants to have the modulus of the body perfect . Where, disproportion occurs in the true See also:dwarf it takes the form of a large-sized head, broad shoulders and capacious See also:chest, and undersized lower limbs . Dwarfs with See also:rickets are perhaps to be distinguished from true dwarfs; these are cases in which the spine is curved, and sometimes the bones of the limbs See also:bent and the See also:pelvis deformed . As in the case of giants, dwarfs are seldom the progeny of dwarfs, who are, in fact, usually sterile; the unnatural smallness may be obvious at birth, but is more likely to make itself See also:manifest in the years of growth . Dwarfs are much more easily brought up than giants, and are stronger and longer-lived; they have usually also strong passions and acute intelligence . The legends of the dwarfs and giants are on the whole well based on fact . (See DWARF and GIANT.) Redundancy and Defect in Single Parts.—The simplest case of this redundancy is a See also:sixth See also:digit, well formed, and provided with muscles (or tendons), nerves, and bloodvessels like the others; it is usually a repetition of the little finger or toe, and it may be present on one or both hands, or on one or both feet, or in all four extremities; as in the giant of See also:Gath . The want of one, two, or more digits on See also:hand or foot, or on both, is another simple See also:anomaly; and, like the redundancy, it is See also:apt to repeat itself in the same See also:family . J . F . Meekel saw a girl who had an extra digit on each extremity, while a See also:sister wanted four of the fingers of one hand . Where the supernumerary digits are more than one on each extremity, the whole set are apt to be rudimentary or stunted; they look as if two or more of the embryonic buds had been subject to cleavage down the See also:middle and to See also:arrest of See also:longitudinal growth . There are several See also:authentic instances of a whole lower See also:limb appearing at birth as two withered halves, as if from embryonic cleavage . Other redundancies of the See also:skeleton are extra vertebrae . (sometimes the See also:coccygeal, giving the See also:appearance of a rudimentary tail), or an extra See also:rib . A double See also:row of See also:teeth is occasionally met with; the most interesting case of this anomaly is that in which the rudiments of a double row exist from the first, but the phenomenon is sometimes produced by the See also:milk teeth persisting along with the second set . Among redundancies of the soft parts, by far the most frequent relate to the mammary glands and especially to the nipples . These See also:organs are normally paired amongst mammals, and the glands of each pair are placed symmetrically on a curved See also:line See also:running from the axilla towards the pubes . When many pairs occur, the glands of each pair diverge less from the median line than those of the immediately anterior pair, the abdominal glands lying See also:close together, those towards the axilla being farther apart . When only a single pair is normally present, the pair is abdominal, See also:pectoral or axillary; and whether the normal be one pair or many pairs, additional glands are not infrequent, but occupy the expected position on the mammary lines, See also:Accessory glands ornipples in human beings, if anterior to the normal pair, See also:lie farther from the median ventral line, and See also:vice versa . Among the sense-organs there is a remarkable instance recorded of doubling of the appendages of the See also:left See also:eye, but not of the eyeball itself; the left See also:half of the frontal bone is double, making two eye-sockets on that side, and the extra See also:orbit has an eyebrow and eyelid . The See also:external See also:ear (pinna) has also been found double on one side and its orifice has frequently been found doubled in See also:man and lower animals, and the additional ears lie in a definite relation to the branchial clefts of the embryo . Doubling of any of the See also:internal organs or parts of organs may occur and innumerable cases have been recorded . Montrosities from Defective See also:Closure in the Middle Line.—Under this head come some of the commonest congenital malformations, including slight deficiencies such as harelip, and serious defects such as a See also:gap in the See also:crown of the head with See also:absence of the brain . The embryo is originally a circular flattened disk spread out on one See also:pole of the yolk, and it is formed into a cylindrical body (with four appendages) by the See also:free margins of the disk, or rather its ventral laminae, folding inwards to meet in the middle line and so close in the pelvic, abdominal, thoracic, pharyngeal and oral cavities . Meanwhile, and indeed rather earlier, two longitudinal parallel ridges on the See also:top or along the back of the disk have grown up and See also:united in the middle line to form the second See also:barrel of the body—the neural See also:canal—of small and See also:uniform width in the lower three-fourths or See also:spinal region, but expanding into a wide chamber for the brain . This See also:division into neural (dorsal) and haemal (ventral) canals underlies all vertebrate development . Imperfect closure along either of those embryonic lines of junction may produce various degrees of monstrosity . The simplest and commonest form, hardly to be reckoned in the present See also:category, is harelip with or without cleft See also:palate, which results from defective closure of the ventral laminae at their extreme upper end . Another simple form, but of much more serious import, is a gap left in the neural canal at its lower end; usually the See also:arches of the lumbar vertebrae are deficient, and the fluid that surrounds the spinal See also:cord bulges out in its membranes, producing a soft See also:tumour under the skin at the lower part of the back . This is the See also:condition known as hydrorhachis, depending on the osseous defect known as See also:spina bifida . More rarely the gap in the arches of the vertebrae is in the region of the See also:neck . If it extend all along the back, it will probably involve the skull also . Deficiency of the crown of the head, and in the spine as well, may be not always traceable to want of formative See also:power to close the canal in the middle line; an over-distended condition of the central canal of the cord and brain may prevent the closure of the bones, and ultimately See also:lead to the disruption of the See also:nervous organs themselves; and injuries to the See also:mother, with inflammation set up in the foetus and its appendages, may be the more remote cause . But it is by defect in the middle line that the See also:mischief manifests itself, and it is in that anatomical category that the malformations are included . The osseous deficiency at the crown of the head is usually accompanied by want of the See also:scalp, as well as of the brain and membranes . The bones of the face may be well See also:developed and the features See also:regular, except that the eyeballs bulge forward under the closed lids; but there is an abrupt See also:horizontal line above the orbits where the bones cease, the skin of the brow joining on to a spongy See also:kind of See also:tissue that occupies the sides and See also:floor of the cranium . This is the commonest form of an anencephalous or brainless monster . There are generally See also:mere traces of the brain, although, in some rare and curious instances, the hemispheres are developed in an exposed position on the back of the neck . The See also:cranial nerves are usually perfect, with the exception sometimes of the optic (and retina) . Vegetative existence is not impossible, and a brainless monster has been known to survive sixty-five days . The See also:child is usually a very large one . Closely allied, as we have seen, to the anencephalous condition is the condition of congenital hydrocephalus . The nervous See also:system at its beginning is a neural canal, not only as regards its bony covering, but in its interior; a wide space lined by ciliated epithelium and filled with fluid extends along the See also:axis of the spinal cord, and expands into a See also:series of See also:chambers in the brain . As development proceeds the walls thicken at the expense of the internal spaces, the See also:original tubular or chambered See also:plan of the central nervous system is departed from, and those organs assume the practically solid form in which we familiarly know them . If, however, the spaces persist in their embryonic proportions notwithstanding the thickening of the nervous substance forming their walls, there results an enormous brain which is more than half occupied inside with fluid, contained in spaces that correspond on the whole to the ventricles of the brain as normally bounded . A hydrocephalic foetus may survive its birth, and will be more apt to be affected in its See also:nutrition than in its intelligence . In many cases the hydrocephalic condition does not come on till after the child is born . Returning to the ventral middle line, there may be defects of closure below the lips and palate, as in the See also:breast-bone (fissure of the sternum), at the See also:navel (the last point to close in any case), and along the middle line of the See also:abdomen generally . The commonest point for a gap in the middle line of the belly is at its lower part, an See also:inch or two above the pubes . At that point inthe embryo there issues the allantois, a See also:balloon-like expansion from the ventral cavity, which carries on its See also:outer See also:surface See also:blood-vessels from the embryo to interdigitate with those of the mother on the uterine surface . Having served its temporary purpose of carrying the bloodvessels across a space, the balloon-like allantois collapses, and rolls up into the rounded See also:stem-like umbilical cord through most of its extent; but a portion of the See also:sac within the body of the foetus is retained as the permanent urinary See also:bladder . That economical See also:adaptation of a portion of a vesicular See also:organ, originally formed for purposes of communication between the embryo and the mother, appears to See also:entail sometimes a defect in the See also:wall of the abdomen just above the pubes, and a defect in the anterior wall of the bladder itself . This is the distressing congenital condition of fissure of the urinary bladder, in which its interior is exposed through an opening in the skin; the pubic bones are separated by an See also:interval, and the reproductive organs are See also:ill-formed; the urachus is wanting, and the umbilicus is always placed exactly at the upper end of the gap in the skin . A monstrosity recalling the cloacal arrangement of the See also:bird is met with as a more extreme defect in the same parts . Hermaphroditism.—Although this anomalous condition does not fall under defective closure in the middle line, it may be said to be due to a similar failure of purpose, or to an uncertainty in the See also:nisus formativus at a corresponding See also:stage of development . Strictly speaking, a hermaphrodite is a creature containing ovaries and testes—the essential organs of each See also:sex . See also:Evidence accumulates, however, that at least in all the higher vertebrates, including man, the sex is predetermined in the fertilized ovum, and it is more than doubtful if true hermaphroditism occurs . On the other hand, if there be no such double sex in the essential organs (as in the See also:majority of so-called hermaphrodites) there is a great See also:deal of doubling and See also:ambiguity entailed in the secondary or external organs and parts of See also:generation . Those parts which are rudimentary or obsolete in the male but highly developed in the female, and those parts which are rudimentary in the female but highly developed in the male tend in the hermaphrodite to be developed equally, and all of them badly . Amongst human beings the greater number of so-called hermaphrodites are really See also:females, in which there is an abnormal development of the clitoris, but it also happens that true See also:males may be born with a small clitoris-like penis, with hypospadia—that is to say, with imperfect urethra, open on the ventral side, and with undescended testes . Failure of the development of the testes or ovary, or their removal in the adult condition induces an ambiguous condition of the body in which the secondary sexual characters approach those of the other sex . Experimental removal of the ovaries or testes, followed by implantation of organs of the other sex, has produced an See also:inversion of the secondary sexual characters .
Cyclops, Siren, &c.—The same feebleness of the formative See also:energy which gives rise to some at least of the cases of defective closure in the middle line, and to the cases of ambiguous sex, leads also to imperfect separation of symmetrical parts
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The most remarkable case of the kind is the cyclops monster
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At a point corresponding to the See also:root of the See also:nose there is found a single orbital cavity, sometimes of small size and with no eyeball in it, at other times of the usual size of the orbit and containing an eyeball more or less See also:complete
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In still other cases, which indicate the nature of the anomaly, the orbital cavity extends for some distance on each side of the middle line, and contains two eyeballs lying close together
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The usual nose is wanting but above the single orbital cavity there is often a nasal See also:process on the forehead, with which nasal bones may be articulated, and cartilages joined to the latter; these form the framework of a short fleshy protuberance like a small See also:proboscis
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The lower jaw is sometimes wanting in cyclopeans; the cheek-bones are apt to be small, and the mouth a small See also:round hole, or altogether absent; the See also:rest of the body may be well developed
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The See also: The monstrosity is not uncommon among the domestic animals, and is especially frequent in the See also:pig . Another curious result of defective separation. of symmetrical parts is the siren form of foetus, in which the lower limbs occur as a single tapering prolongation of the See also:trunk like the hinder part of a See also:dolphin, at the end of which a foot (or both feet) may or may not be visible . The defects in the bones underlying this siren form are very various: in some cases there is only one limb (thigh and See also:leg-bones) in the middle line; in others all the bones of each limb are present in more or less rudimentary condition, but adhering at prominent points of the adjacent surfaces . The pelvis and pelvic viscera See also:share in the abnormality . A much more common and harmless case of unseparated symmetrical parts is where the hand or foot has two, three, or more digits fused together . This syndactylous anomaly runs in families . Limbs Absent or Stunted.—Allied to these fused or unseparated states of the extremities, or of parts of them, are the class of deformities in which whole limbs are absent, or represented only by stumps . The trunk (and head) may be well formed, and the individual healthy; all four extremities may be reduced to short stumps either wanting hands and feet entirely, or with the latter fairly well developed; or the legs only may be rudimentary or wanting, or the arms only, or one extremity only . Although some of these cases doubtless depend upon aberrant or deficient formative power in the particular directions, there are others of them referable to the effects of See also:mechanical pressure, and even to See also:direct amputation of parts within the uterus . Acardiac and Acranial Monsters.—It sometimes happens in a twin pregnancy that one of the embryos fails to develop a heart and a complete vascular system of its own, depending for its nourishment upon blood derived from the See also:placenta of its well-formed twin by means of its umbilical vessels . It grows into a more or less shapeless See also:mass, in which all traces of the human form may be lost . Other viscera besides the heart will be wanting, and no head distinguishable; the most likely parts to keep the line of development are the lumbar region (with the kidneys), the pelvis, and the lower limbs . The twin of this monster may be a healthy See also:infant . Reversed Position of the Viscera.— This is a developmental See also:error associated with the retention of the right aortic See also:arch as in birds, instead of the left as is usual in mammals . The position of all the unsymmetrical viscera is transposed, the See also:spleen and cardiac end of the See also:stomach going to the right side, the See also:liver to the left, the caecum resting on the left iliac fossa, and the sigmoid flexure of the See also:colon being attached to the right . This condition of situs inversus viscerum need cause no inconvenience; and it will probably remain undetected until the occasion should arise for a See also:physical diagnosis or See also:post-mortem inspection . The causes of congenital anomalies are difficult to specify . There is no doubt that, in some cases, they are present in the sperm or germ of the See also:parent; the same anomalies recur in several See also:children of a family, and it has been found possible, through a variation of the circumstances, to trace the See also:influence in some cases to the See also:father alone, and in other cases to the mother alone . The remarkable thing in this743 parental influence is that the malformation in the child may not have been manifested in the body of either parent, or in the grandparents . More often the malformation is acquired by the embryo and foetus in the course of development and growth, either through the mother or in itself independently . Maternal impressions during pregnancy have often been alleged as a cause, and this See also:causation has been discussed at great length by the best authorities . The See also:general See also:opinion seems to be that it is impossible to set aside the influence of subjective states of the mother altogether, but that there is no direct. connexion between the cause of the subjective state and the resulting anomaly . The See also:doctrine of maternal impressions has often been resorted to when any other explanation was either difficult or inconvenient; thus, See also:Hippocrates is said to have saved the virtue of a woman who gave birth to a See also:black child by pointing out that there was a picture of a See also:negro on the wall of her chamber . Injuries to the mother during pregnancy have been unquestionably the cause of certain malformations, especially of congenital hydrocephalus . The embryo itself and its membranes may become the subject of inflammations, atrophies, hypertrophies, and the like; this causation is doubtless accountable for a See also:good many of them . But a very large See also:residue of malformations must still be referred to variation in the embryonic cells and See also:cell-See also:groups . The nisus formativus of the fertilized ovum is always subject to morphological See also:laws, but, just as in extra-uterine life, there may be deviations from the beaten track; and even a slight deviation at an early stage will carry with it far-reaching consequences . This is particularly noticeable in double monsters . 2 . Double Monsters.—Twins are the physiological See also:analogy of double monsters, and some of the latter have come very near to being two separate individuals . The Siamese twins, who died in 1874 at the See also:age of sixty, were joined only by a thick fleshy See also:ligament from the lower end of the breast-bone (xiphoid See also:cartilage), having the common navel on its lower border; the anatomical examination showed, however, that a process of peritoneum extended through the ligament from one abdominal cavity to the other, and that the blood-vessels of the two livers were in free communication across the same See also:bridge . There are one or two cases on record in which such a ligament has been cut at birth, one, at least, of the twins surviving . From the most intelligible form of double monstrosity, like the Siamese twins, there are all grades of fantastic See also:fusion of two individuals into one down to the truly marvellous condition of a small body or fragment parasitic upon a well-grown infant—the condition known as foetus in foetu . These monstrosities are deviations, not from the usual kind of twin gestation, but from a certain rarer physiological type of dual development . In by far the majority of cases twins have separate uterine appendages, and have probably been developed from distinct ova; but in a small proportion of (recorded) cases there is evidence, in the placental and enclosing structures, that the twins had been developed from two rudiments arising side by side on a single blastoderm . It is to the latter physiological category that double monsters almost certainly belong; and there is some direct embryological evidence for this opinion . See also:Allen See also:Thomson observed in the blastoderm of a See also:hen's See also:egg at the sixteenth or eighteenth See also:hour of See also:incubation two "See also:primitive traces" or rudiments of the backbone forming side by side; and in a See also:goose's egg incubated five days he found on one blastoderm two embryos, each with the rudiments of upper and lower extremities, See also:crossing or cohering in the region of the future neck, and with only one heart between them . A very large number of similar observations have been published and appear to be found in all cases where a large material is available . The developing ova of See also:fish, available in large See also:numbers in hatcheries, and the laboratory investigation of the chick and the See also:frog have provided cases of almost every degree of blending . The perfect physiological type appears to be two rudiments on one blastoderm, whose entirely separate development produces twins (under their rarer circumstances), whose nearly separate development produces such double monsters as the Siamese twins, and whose less separate development produces the various See also:grotesque forms of two individuals in one body . There can be no question of a literal fusion of two embryos; either the individuality of each was at no time complete, or, if there were two distinct primitive traces; the uni-axial type was approximately reverted to in the process of development, as in the formation of the abdominal and thoracic viscera, limbs, pelvis or head . Double monsters are divided in the first instance into those in which the doubling is symmetrical and equal on the two sides, and those in which a small or fragmentary foetus is attached to or enclosed in a foetus of See also:average development—the latter class being the so-called cases of " See also:parasitism." Symmetrical Double Monsters are subdivided according to the part or region of the body where the See also:union or fusion exists —head, See also:thorax, umbilicus or pelvis . One of the simplest cases is a Janus head upon a single body, or there may be two pairs of arms with the two faces . Again, there may be one head with two necks and two complete trunks and pairs of extremities . Two distinct heads (with more or less of neck) may surmount a single trunk, broad at the shoulders but with only one pair of arms . The fusion, again, may be from the middle of the thorax downwards, giving two heads and two pairs of shoulders and arms, but only one trunk and one pair of legs . In another variety, the body may be double down to the See also:waist, but the pelvis and lower limbs single . The degree of union in the region of the head, abdomen or pelvis may be so slight as to permit of two distinct organs or sets of organs in the respective cavities, or so great as to have the viscera in common; and there is hardly ever an intermediate condition between those extremes . Thus, in the Janus head there may be two brains, or only one brain . The Siamese twins are an instance of union at the umbilical region, with the viscera distinct in every respect except a slight vascular See also:anastomosis and a common process of peritoneum; but it is more usual for union in that region to be more extensive, and to entail a single set of abdominal and thoracic viscera . The pelvis is one of the commonest regions for double monsters to be joined at, and, as in the head and abdomen, the junction may be slight or See also:total . The Hungarian sisters See also:Helena and See also:Judith (1701–1723) were joined at the sacrum, but had the pelvic cavity and pelvic organs separate; the same condition obtained in the See also:South Carolina negresses Millie and See also:Christina, known as the " two-headed See also:nightingale," and in the Bohemian sisters Rosalie and Josepha . More usually the union in the pelvic region is complete, and produces the most fantastic shapes of two trunks (each with head and arms) joining below at various angles, and with three or four lower limbs extending from the region of fusion, sometimes in a lateral direction, sometimes downwards . A very curious kind of double monster is produced by two otherwise distinct foetuses joining at the crown of the head and keeping the axis of their bodies in a line . It is only in rare instances that double monsters survive their birth, and the preserved specimens of them are mostly of foetal size . Unequal Double Monsters, Foetus in Foetu.—There are some well-authenticated instances of this most curious of all anomalies . The most celebrated of these See also:parasite-bearing monsters was a Genoese, See also:Lazarus Johannes Baptista Colloredo, born in 1716, who was figured as a child by Licetus, and again by See also:Bartholinus at the age of twenty-eight as a See also:young man of average stature . The parasite adhered to the lower end of his breast-bone, and was a tolerably well-formed child, wanting only one leg; it breathed, slept at intervals, and moved its body, but it had no separate nutritive functions . The parasite is more apt to be a See also:miniature acardiac and See also:acephalous fragment, as in the case of the one See also:borne in front of the abdomen of a Chinaman figured by I . Geoffroy St Hilaire . Sometimes the parasite is contained in a pouch under the skin of the abdominal wall, and in another class (of which there is a specimen in the Hunterian Museum) it has actually been included, by the closure of the ventral laminae, within the abdominal cavity of the foetus—a true foetus in foetu . Shapeless parasitic fragments containing masses of bone, cartilage and other tissue are found also in the space -behind the breast-bone (mediastinal teratoma), or growing fromthe See also:base of the skull and protruding through the mouth ("epignathous teratoma," appearing to be seated on the jaw), and, most frequently of all, attached to the sacrum . These last pass by a most interesting transition into common forms of congenital. sacral tumours (which may be of enormous size), consisting mainly of one kind of tissue having its physiological type in the curious gland-like body (coccygeal gland) in which the middle sacral artery comes to an end . The congenital sacral tumours have a tendency to become cystic, and they are probably related to the more perfect congenital cysts of the neck region, where there is another See also:minute gland-like body of the same nature as the coccygeal at the point of bifurcation of the common See also:carotid artery . Other tumours of the body, especially certain of the sarcomatous class, may be regarded from the point of view of monstra per excessum; but such cases suggest not so much a question of aberrant development within the blastoderm as of the indwelling spontaneity of a single post-embryonic tissue . (See TUMOUR AND See also:PATHOLOGY.) Monstrosities in man and animals have attracted See also:attention since the earliest times, and amongst primitive and uncivilized peoples have been regarded as of supernatural origin . See also:Aristotle himself appears to have been the first to examine them as a naturalist, and to explain that although they were outside the usual course of nature they were in the strictest sense of natural origin . See also:Pliny described many well-known forms, but did not distinguish between legendary and actual monstrosities . In the middle ages they were treated in the fullest spirit of superstition, and many See also:relics from such a point of view still survive . The human monstrosities were regarded as having been engendered in See also:women by the See also:devil who had See also:commerce with them either in his own form or in the See also:guise of some animal . The belief still to be found amongst uneducated persons that unnatural union between women and male animals, or between men and female animals, may be fertile and produce monsters, is an attenuated form of the satanic See also:legend . The scientific appreciation of monsters has grown with the study of See also:embryology .
See also: F . Meckel at the beginning of the 19th See also:century, did not recognize the influence of physiological causes in the See also:production of abnormalities; they believed the latter to proceed certainly in an orderly and natural way, but from abnormal ova . E . G . St Hilaire was the first to See also:attempt experimental teratology and to See also:lay down that many monstrosities were the result of influences causing deviations from the normal course of embryonic development . I . G . St Hilaire, the son of E . G . St Hilaire, carried the experimental method little further, but published an elaborate descriptive See also:treatise on anomalies (See also:Paris, 1832–1837) which remains one of the most valuable records of the subject . A similar treatise with an incomparable See also:atlas of illustrations was issued by W . Vrolik, the great Dutch anatomist, between 184o and 1849, whilst A . See also:Forster issued in x861 a valuable textbook with a very large number of illustrations chiefly from preparations in the museum at See also:Wurzburg . The great museums devoted much attention to the collection and display of malformations, and no See also:account of the subject can be adequate which does not include reference to the magnificent series in the Museum of the Royal College of Surgeons of See also:England, with the descriptive catalogues of the animal malformations written by B . T . Lowne (1893) and of the See also:vegetable malformations by M . T . Masters (1893) . The See also:work hitherto referred to, as well as a vast bulk of scattered contributions to teratology throughout the ,9th century, was chiefly descriptive, anatomical and embryological teratology, and carried the experimental side little beyond where it had been left by the St Hilaires . In 1891 Camille Dareste published his Recherches sur la production artificielle See also:des monstruosites, ou essais de teratogenie experimentale; his experiments, chiefly on the developing egg of the See also:fowl, not only showed the probable cause of many of the most common abnormalities, but practically created a new See also:branch of science, experimental embryology . Teratology has since become a side issue of the general study of the inter-relations between the inherited tendencies of the developing organism and the See also:play of the circumambient See also:media, and must be studied in relation to the work of O . Hertwig, W . Roux, H . Driesch, O . Butschli, J . Loeb and their school . J . Bla:1d See also:Sutton's popular See also:Evolution and Disease (1890) puts in a cogent way the relation between See also:comparative anatomy and common abnormalities, whilst W . See also:Bateson in his Materials for the Study of Variation (1894) describes the acquisition of new symmetries by abnormal organs, and discusses the possible relation between abnormalities and the origin of species . E . Schwalbe's Morphologie der Missbildungen (1906-1909) is a very complete study of the most See also:modern developments of teratology, and contains a careful and elaborate See also:list of authorities from the earliest times . (C . C.; P . C . |
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