NERVE ENDINGS  .—Sensory nerves end by breaking up into fibrillae or by various tactile organs . In the former case the minute fibrils, of which it has been shown that the axons or nerve fibres consist, separate and end among epithelial cells of the mucous membrane or skin . In the latter case the nerve fibres lose their coating of myelin and end in one of the seven following organs: I . End bulbs of Krause (fig . 3, A), oval bulbs composed of elongated cells among which the nerve fibrils end in knobs or coils; each is surrounded by a sheath of neurilemma, and the organs are found in the lips, tongue, conjunctiva, epineurium of nerves, synovial membranes of joints, and in the glans penis et clitoridis, where they have a mulberry-like appearance . 2 . Pacinian corpuscles (fig .. 3, B) are large enough to be seen by the naked eye, and are oval bodies made up of a series of concentric capsules of connective tissue rather resembling the structure of an onion; in the centre of this is a structureless core, at the distal extremity of which the nerve fibre ends in one or more knobs . These Cunningham's Text-Book of Anatomy . bodies are found in the palm and sole, in the mesentery, the genital organs and in joints . 3 . Tactile corpuscles of Meissner and Wagner (fig .

3, C) aregval bodies found in certain of the skin papillae and mucous membrane, especially of very sensitive parts like the

hand and foot, lips, tongue and nipple . They are oval and made of a connective tissue capsule from which septa enter the interior . The nerve fibre generally takes a spiral course through them, loses its myelin sheath, and ends by breaking up into its fibrils, which eventually become bulbous . 4 . Tactile corpuscles of Grandry are found in the skin of those parts devoid of hair, and consist of a capsule containing two or more A B From Robert Howden, in Cunningham's Text-Book of Anatomy . of Pacini; C, Corpuscle of Meissner . (B, C, after Ranvier.) largish cells, between which the nerve fibre ends in the so-called tactile discs . 5 . Kuffini's endings are flattened oval bodies with a thick connective tissue capsule, in which the nerve fibre divides into many common to the whole system, or for which a place does not 6 . Organs of Golgi are found in tendons . Nerve fibres penetrate the tendon bundles and divide in a tree-like manner to end in little disks and varicosities . 7 .

Neuro-

muscular spindles are small fusiform bundles of embryonic muscle fibres among which the nerve fibres end by en-circling them and forming flattened disks . These are sensory endings, and must not be confused with the motor end plates . They are found in most of the striped muscles of the body . Motor nerves end in striped muscle by motor end plates . These are formed by a nerve fibre approaching a muscle fibre and suddenly losing its myelin sheath while its neurilemma becomes continuous with the sarcolemma of the muscle fibre . The axis cylinder divides, and its ramifications are surrounded by a disk of granular matter containing many clear nuclei . In very long muscle fibres more than one of these end plates are sometimes found . Involuntary motor endings are usually found in sympathetic nerves going to unstriped muscle . The fibres form minute plexuses, at the points of union of which small triangular ganglion cells are found . After this the separate fibrils of the nerve divide, and each ends opposite the nucleus of an unstriped muscle cell .