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TYPHUS FEVER (from Gr. ri 4 os, smoke...

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Originally appearing in Volume V27, Page 509 of the 1911 Encyclopedia Britannica.
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TYPHUS See also:

FEVER (from Gr. ri 4 os, See also:smoke or mist, in allusion to the stupor of the disease)  , an acute infectious disease of highly contagious nature, lasting for about fourteen days, and characterized mainly by See also:great prostration of strength,severe See also:nervous symptoms, and a See also:peculiar eruption on the skin . It has received numerous other names, such as pestilential, putrid, jail, See also:hospital See also:fever, exanthematic typhus, &c . It appears to have been known for many centuries as a destructive malady, frequently appearing in epidemic See also:form, in all countries in 'See also:Europe, under the conditions to be afterwards referred to . The best accounts of the disease are those given by old See also:English writers, who narrate its ravages in towns and describe many " See also:black assizes," in which it was communicated by prisoners brought into See also:court to the See also:judges, jurymen, court officials, &c., with fatal effect . Typhus fever would seem to have been observed in almost all parts of the See also:world; but it has most frequently prevailed in temperate or See also:cold climates . The conditions concerned in its See also:production include both the predisposing and the exciting . Of the former the most powerful are those influences which See also:lower the See also:health of a community, especially overcrowding and poverty . Hence this fever is most frequently found to affect the poor of large cities and towns, or to appear where large See also:numbers of persons are living crowded together in unfavourable hygienic conditions, as has often been seen in prisons, workhouses, &c . Armies in the See also:field are also liable to suffer from this disease; for instance, during the See also:Crimean See also:War it caused an enormous mortality among the See also:French troops . Recently, however, an important See also:change of view of the connexion of typhus fever has arisen . See also:Professor See also:Matthew See also:Hay (See also:Journal of Public Health, See also:September 1907) attributes the spread of typhus fever to fleas . His observations are based on the epidemic in See also:Aberdeen .

He sums up his conclusions in the following manner: (1) Every See also:

case in hospital examined by Professor Hay and his assistants was See also:flea bitten, and those of the See also:staff who complained of flea bites were attacked . Care was exercised to distinguish between flea bites and petechiae . (2) Where a patient was apparently See also:free from bites it was found he had been in contact with verminous families . (3) The disease did not spread in clean houses with clean inhabitants, even when a typhus patient remained in the dwelling during his entire illness . (4) All nurses or wards-maids who were attacked were in contact with the patients when they were first admitted . No See also:nurse, wards-maid or See also:doctor who had been in See also:close contact with the cases when cleaned contracted the disease: (5) An See also:ambulance See also:driver who complained of being pestered by fleas contracted typhus fever, but when the ambulance staff were adequately protected from fleas no other cases See also:developed . Typhus is now regarded as certainly due to the See also:action of some specific micro-organism (see PARASITIC DISEASES), but the See also:bacteriology is still imperfect . In 1891 Jaroslav Hlava, of See also:Prague, found in the See also:blood of 20 out of 33 cases of typhus a well-defined organism which he termed the strepto-bacillus . Lewaschew in 1892 found in the blood and See also:spleen of typhus patients small See also:round highly refractive actively-moving bodies lying between the corpuscles . Sometimes these bodies were flagellate . Dubieff and See also:Bruhl also found a diplococcus in the blood which they named the diplococcus exanthematicus . The course of typhus fever is characterized by certain well-marked stages .

1 . The See also:

stage of See also:incubation, or the See also:period elapsing between the reception of the fever See also:poison into the See also:system and the manifestation of the See also:special See also:evidence of the disease, is believed to vary from a See also:week to ten days . During this See also:time, beyond feelings of languor, no particular symptoms are exhibited . 2 . The invasion of the fever is in See also:general well marked and severe, in the form of a distinct rigor, or of feelings of chilliness lasting for See also:hours, and a sense of illness and prostration, together with headache of a distressing See also:character and sleeplessness . Feverish symptoms soon appear and the temperature of the See also:body rises to a considerable height (103°–105°F.), at which it continues with little daily variation until about the period of the crisis . It is, however, of importance to observe certain points connected with the temperature during the progress of this fever . Thus about the seventh See also:day the See also:acme of the fever See also:heat has been reached, and a slight subsidence (I° or less) of the temperature takes See also:place in favourable cases, and no further subsequent rise beyond this lowered level occurs . When it is otherwise, the case often proves a severe one . Again, when the fever has advanced towards the end of the second week, slight falls of temperature are often observed, See also:prior to the extensive descent which marks the attainment of the crisis . The See also:pulse in See also:HISTORY] typhus fever is rapid (1oo-12o or more) and at first full, but later on feeble . Its See also:condition as indicating the strength of the See also:heart's action is watched with anxiety .

The See also:

tongue, at first coated with a See also:white See also:fur, soon becomes See also:brown and dry, while sordes (dried mucus, &c.) accumulate upon the See also:teeth; the appetite is gone; and intense thirst prevails . The bowels are as a See also:rule constipated, and the urine is diminished in amount and high coloured . The physician may make out distinct enlargement of the spleen . 3 . The third stage is characterized by the See also:appearance of the eruption, which generally shows itself about the See also:fourth or fifth day or later, and consists of dark red (mulberry-coloured) spots or blotches varying in See also:size from See also:mere points to three or four lines in See also:diameter, very slightly elevated above the skin, at first disappearing on pressure, but tending to become both darker in See also:hue and more permanent . They appear chiefly on the See also:abdomen, sides, back and limbs, and occasionally on the See also:face . Besides this characteristic typhus rash, there is usually a general faint mottling all over the See also:surface . The typhus rash is rarely absent and is a very important diagnostic of the disease . In the more severe and fatal forms of the fever the rash has all through a very dark See also:colour, and slight subcutaneous haemorrhages (petechiae) are to be seen in abundance . After the appearance of the eruption the patient's condition seems to be easier, so far as regards the headache and discomfort which marked the outset of the symptoms; but this is also to be ascribed to the tendency to pass into the typhous stupor which supervenes about this time, and becomes more marked throughout the course of the second week . On the examination of the blood a marked leucocytosis is See also:present This is considered to be diagnostic in doubtful cases when the rash is badly marked . The patient now lies on his back, with a dull dusky countenance, an apathetic or stupid expression, and contracted pupils .

Phoenix-squares

All the febrile symptoms already mentioned are fully developed, and See also:

delirium, usually of a See also:low muttering See also:kind, but sometimes See also:wild and maniacal (delirium ferox), is present both by See also:night and day . The peculiar condition to which the See also:term " See also:coma See also:vigil " is applied, in which the patient, though quite unconscious, lies with eyes widely open, is regarded, especially if persisting for any length of time, as an unfavourable See also:omen . Throughout the second week the symptoms continue unabated; but there is in addition great weakness, the pulse becoming very feeble, the breathing shallow and rapid, and often accompanied with bronchial sounds . 4 . A crisis or favourable change takes place about the end of the second or beginning of the third week (on an See also:average the r4th day), and is marked by a more or less abrupt fall of the temperature and of the pulse, together with slight See also:perspiration, a See also:discharge of loaded urine, the return of moisture to the tongue, and by a change in the patient's look, which shows signs of returning intelligence . Although the sense of weakness is extreme, convalescence is in general steady and comparatively rapid . Typhus fever may, however, prove fatal during any stage of its progress and in the See also:early convalescence, either from sudden failure of the heart's action—a condition which is specially See also:apt to arise—from the supervention of some nervous symptoms, such as See also:meningitis or of deepening coma, or from some other complication, such as See also:bronchitis . Further, a fatal result sometimes takes place before the crisis from sheer exhaustion, particularly in the case of those whose See also:physical or nervous energies have been lowered by hard See also:work, inadequate nourishment and See also:sleep, or intemperance . Occasionally troublesome sequelae remain for a greater or less length of time . Among these may be mentioned See also:mental weakness or irritability, occasionally some form of See also:paralysis, an inflamed condition of the lymphatic vessels of one See also:leg (the swelled leg of fever), prolonged weakness and See also:ill health, &c . See also:Gradual improvement, however, may be confidently anticipated and even ultimately recovery . The mortality from typhus fever is estimated by See also:Charles See also:Murchison (183o-1879) and others as averaging about 18% of the cases, but it varies much according to the severity of type (particularly in epidemics), the previous health and habits of the individual, and very specially the See also:age—the proportion of deaths being in striking relation to the advance of See also:life .

Thus, while in See also:

children under fifteen the See also:death-See also:rate is only 5 %, in persons over fifty it is about 46% . The treatment of typhus fever includes the prophylactic See also:measures of See also:attention to the sanitation of the more densely populated See also:por-Treatment. tions of towns . Where typhus has broken out in a crowded See also:district the prompt removal of the patients to a fever hospital and the thorough disinfection and cleansing of the infected houses are to be recommended . Where, however, a single case of accidentally caught typhus occurs in a member of a See also:family inhabiting a well-aired See also:house, the See also:chance of it being communicated to others in the dwelling is small; nevertheless every precaution in the way of See also:isolation and disinfection should be taken . The treatment of a typhus patient is conducted upon the same general principles as in typhoid . See also:Complete isolation should be maintained throughout the illness, and due attention given to the See also:ventilation and cleansing of the sick chamber . Open-See also:air treatment when practicable greatly reduces the temperature . The See also:main See also:element in the treatment of this fever is See also:good See also:nursing, and especially509 the See also:regular See also:administration of nutriment, of which the best form is See also:milk, although See also:light See also:plain soup may also be given . The See also:food should be administered at stated intervals, not, as a rule, oftener than once in one and a See also:half or two hours, and it will frequently be necessary to rouse the patient from his stupor for this purpose . Sometimes it is impossible to administer food by the mouth, in which case recourse must be had to nutrient enemata . Alcoholic stimulants are not often required, except in the case of elderly and weakly persons who have become greatly exhuasted by the attack and are threatening to collapse . When the pulse shows unsteadiness and undue rapidity, and the first See also:sound of the heart is but indistinctly heard by the See also:stethoscope, the prompt administration of stimulants (of which the best form is pure spirit) will often succeed in averting danger .

Should their use appear to increase the restlessness or delirium they should be discontinued and the diffusible (ammoniacal or ethereal) forms tried instead . Many other symptoms demand special treatment . The headache may be mitigated by removing the See also:

hair and applying cold to the See also:head . The sleeplessness, with or without delirium, may be combated by quietness, by a moderately darkened See also:room (although a distinction between day and night should be made as regards the amount of admitted light), and by soothing and See also:gentle dealing on the See also:part of the nurse . Opiate and sedative medicines in any form, although recommended by many high authorities, must be given with great caution, as their use is often attended with danger in this fever, where coma is apt to supervene . When resorted to, probably the safest form is a See also:combination of the bromide of See also:potassium or ammonium with a guarded amount of See also:chloral . Alarming effects sometimes follow the administration of See also:opium . Occasionally the deep stupor calls for remedies to rouse the patient, and these may be employed in the form of See also:mustard or See also:cantharides to the surface (calves of legs, nape of See also:neck, over region of heart, &c.), of the cold affusion, or of enemata containing See also:turpentine . The height of the temperature may be a serious symptom, and antipyretic remedies appear to have but a slight See also:influence over it as compared to that which they possess in typhoid fever, acute See also:rheumatism, &c . See also:Hugo Wilhelm von Ziemssen (1829–1902) strongly recommends See also:baths in hyperpyrexia, the temperature of the See also:bath being gradually reduced by the addition of See also:ice . Cold sponging of the hands and feet and exposed parts, or cold to the head, may often considerably lower the temperature . Throughout the progress of a case the condition of the See also:bladder requires special attention, owing to the patient's drowsiness, and the regular use of the catheter becomes, as a rule, necessary with the advance of the symptoms .

End of Article: TYPHUS FEVER (from Gr. ri 4 os, smoke or mist, in allusion to the stupor of the disease)
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