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Theiler, Max

fever yellow vaccine disease

[ tiy ler] (1899–1972) South African–US virologist: developed 17D vaccine against yellow fever.

Theiler studied medicine in South Africa and in London, and joined the staff of the Rockefeller Foundation in New York in 1930. Before that he had shown that yellow fever was certainly due to a virus, which could be cultured in mice, and he went on to show that by transmitting it from mouse to mouse many times, a safe and standardized vaccine could be mass-produced. On injection into human patients this induces yellow fever infection in an extremely mild form, with the benefit that it is followed by immunity from the full disease because antibodies have been generated in the blood. This vaccine (17D) effectively eliminated yellow fever as a major human disease and completed that work begun by , who had shown in 1901 that the disease was probably due to a virus and was transmitted through mosquito bites. Theiler won the Nobel Prize for physiology or medicine in 1951 ‘for his discoveries concerning yellow fever and how to combat it’.

He was fortunate to survive yellow fever himself in 1929, afterwards having the advantage of immunity.

Then Came Bronson [next] [back] Thebes and the Estate of Amun - NAME AND LOCATION OF THEBES., PRAISE OF THEBES, KARNAK TEMPLE: AMUN’S HOME.

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