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Yanofsky, Charles

mutant amino acid genetic

[ya nof skee] (1925– ) US geneticist: experimentally verified the hypothesis that the DNA base sequence codes for protein synthesis.

A graduate in chemistry from New York who went on to work in microbiology at Yale, Yanofsky afterwards worked at Yale and Stanford on gene mutations. His best-known work was his demonstration of the validity of suggestion of 1953 that the sequence of bases in the genetic material DNA determines the order of the amino acids that make up proteins, including of course the enzymes critical to living systems. Yanofsky secured his evidence on this by ingenious experimentation using mutant strains of a bacterium; these were isolated and the positions of the mutations in the gene were mapped. Likewise, the amino acid sequences were determined in the various mutant forms of the enzyme produced by these strains. It could then be shown that the changes in amino acid sequences correspond with the mutant sites on the genetic map, in accord with the theory.


[ya nof skee] (1925– ) US geneticist: experimentally verified the hypothesis that the DNA base sequence codes for protein synthesis.


A graduate in chemistry from New York who went on to work in microbiology at Yale, Yanofsky afterwards worked at Yale and Stanford on gene mutations. His best-known work was his demonstration of the validity of suggestion of 1953 that the sequence of bases in the genetic material DNA determines the order of the amino acids that make up proteins, including of course the enzymes critical to living systems. Yanofsky secured his evidence on this by ingenious experimentation using mutant strains of a bacterium; these were isolated and the positions of the mutations in the gene were mapped. Likewise, the amino acid sequences were determined in the various mutant forms of the enzyme produced by these strains. It could then be shown that the changes in amino acid sequences correspond with the mutant sites on the genetic map, in accord with the theory.

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